North America Tangential Flow Filtration Market: Industry Analysis and Forecast (2024-2030) Trends

North America Tangential Flow Filtration Market Definition/ Overview

Tangential flow Filtration, also known as cross-flow filtration, is a very important downstream processing technique that is also used in the upstream process of cell harvesting (separation of cells from fermentation broth). The solution is delivered tangentially along the filter's surface, with the pressure difference guiding constituents smaller than the pores through the filter. A wide range of biomolecules, including antibodies, nucleic acids, and recombinant proteins, are separated and purified using tangential flow filtration. This technique has a number of advantages, including the flexibility to be used in a variety of biological domains such as immunology, protein chemistry, molecular biology, biochemistry, and microbiology, as well as its adaptability to a variety of volumes for separation and purification. Tangential flow filtration is used to concentrate and desalt sample solutions that range in size from a few millilitres to thousands of litres. It has various advantages, including easy scaling up and scaling down, simple set-up and operation, and time and money savings.

 

 

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US and Canada being the best contributors for the Tangential flow Filtration in North America. Established biopharmaceutical markets and a massive numbers of Tangential flow Filtration key players from the region drives the market here. Moreover, applications of membrane filtration in pharma sector and new technological innovations also drives the Tangential flow Filtration in North America.

 

North America Tangential Flow Filtration Market Dynamics

 

North America Tangential Flow Filtration Market Drivers

 

Strong Economies of North America – Countries like US and Canada contribute a lot to the Tangential Flow Filtration Market in North America. Because the US has many essential and key players, as well as large pharmaceutical and biopharmaceutical companies with increasing investments, the US is the most important contributor to market dominance and growth. Membrane filters are also gaining popularity in the pharmaceutical industry due to its advantages over dead-end filters, such as higher efficiency, greater accuracy, and shorter filtration times. Due to pharmaceutical industry expenditures and a rise in biologics and CMOS production, Canada has a significant impact on the Tangential Flow Filtration Market in North America. Furthermore, factors such as high money availability and investments in Tangential Flow Filtration Market research and development help to grow the Canadian and thus the North American markets.

 

Developments, International Mergers, technological Innovations by Key players from the region - The TFDF (Tangential Flow Depth Filtration) approach was developed by Repligen Corporation (Repligen) for extracting lentiviral vectors from cell culture supernatant in the bioreactor. Using the TFDF approach, cells and cell detritus were efficiently isolated from vector particles. Harvest yields of more than 90% were common, with flux rates ranging from 700 to 750 litres/m2/hour (LMH) at both the 5 and 50 L scales. In a perfusion mode, the tangential mode of TFDFTM was discovered to be gentle enough on the cells to tolerate several harvests, allowing for considerably increased LV vector generation. Because of these technical improvements, Tangential Flow Filtration is expected to grow at a significant rate between 2024 and 2030. There have been several international mergers, which may assist the market grow in North America with more financing and labour. For example, in December 2021, Donaldson Company (US) purchased Solaris (Italy), a company that designs and manufactures bioprocessing equipment, particularly tangential flow filtration systems for use in biotechnology and other life sciences applications. As a result of this transaction, the company's pharmaceutical portfolio will be expanded.

 

Advantages over Normal Flow Filtration (NFF) – In, North America Tangential Flow Filtration is preferred over Normal Flow Filtration due to its advantages. Tangential flow filtration (TFF) has a number of advantages over normal flow filtration (NFF) that make it a better choice for upstream and downstream processing in pharmaceutical and biopharmaceutical applications. NFF, or dead-end filtration, is a batch operation with drawbacks such as lower flow rates, the need for filter aids, frequent filter cleaning or replacement, and the creation of filter cakes, which can lead to membrane fouling. TFF, unlike NFF, is a continuous process that permits the feed to flow continuously across the membrane. This shortens the entire filtering process and allows for the operation of a continuous, automated filtration system. TFF also provides better flow rates, high-end product quality, increased productivity, total cost savings, and minimum filter cake formation, which decreases membrane fouling and so extends the membrane's shelf life. TFF also uses single-use solutions to reduce cross-contamination of the final product.

 

High Capital Investment – The high capital expenditure required to build up new production facilities, as well as the easy availability of product equivalents such as pre-coat filtration, centrifugation, and direct flow filtration, are projected to stifle market expansion in North America. Complications caused by the interaction of charged excipients and proteins, as well as strict government rules and regulations, are likely to pose a challenge to the tangential flow filtration market in North America during the forecast period of 2024-2030.

 

Difficulty for entry and survival of small players - In 2021, the market is highly consolidated, with top companies such as Danaher Corporation (US), Merck Millipore (US) and Synder Filtration Inc. (US) accounting for the majority of market share. These well-known companies offer a wide range of filtration solutions for sterile filtration, protein purification, and virus clearance, among other applications. Furthermore, the market's top companies are huge and well-established, with a high level of brand loyalty. New entrants must compete with established competitors and differentiate themselves by establishing novel product offers and superior technologies.

 

North America Tangential Flow Filtration Market Segment Analysis

By Product, the North America Tangential Flow Filtration Market is segmented as Single-use TFF Systems, Reusable TFF Systems, Membrane Filters, and Filtration Accessories. Single-use TFF systems has the market share of 40% in 2023 due to its benefits such as less cross-contamination, more flexibility, and reduced process time, as well as increased use of techniques such as microfiltration and microfiltration is the most popular technology in North America in this sector so that drives this segment’s market in North America and by fully automated single-use systems, which offer benefits such as less validation, lower capital costs, and fewer cleaning requirements. Reusable TFF Systems has the market share of 24% in 2023 and is less than that of global share as people this is not well accepted by people here in North America as in other parts of the world but in long run the cost of using these TFFs is very low and as the name suggests, can be reused. It does hinder the quality of filtrations but has some advantages like microfiltration, benefits such as ease of use, quicker application, and greater effectiveness. Filtration accessories are costly and have limited use and that is why the market share of 15% have in 2023. Membrane filters have the market share of 21% in 2023 due to many applications in biopharmaceutical sector which is quite popular in this region.

 

 

By Technology, the North America Tangential Flow Filtration Market is segmented as Ultrafiltration, Microfiltration, Reverse Osmosis, and Nanofiltration. In 2023, Microfiltration will have a 35 %, while Reverse Osmosis will have a 31 %. Because of the increasing use of microfiltration in tangential flow filtration for a variety of applications such as concentration and desalting of protein, peptide, and oligonucleotide solutions, microfiltration is at the top of the list. Tangential-flow microfiltration can be used to clarify difficult-to-filter solutions like crude plant extracts, which induce membrane fouling quickly when employing typical dead-end filtration techniques, fuelling the expansion of the industry. Because of the increasing usage of reverse osmosis in water purification and its greater cost-effectiveness when compared to traditional evaporation techniques, reverse osmosis has the greatest market share and is the fastest growing segment in North America. Because of their restricted industrial use and ultra-high cost, Ultrafiltration has a market share of % in 2023, followed by Nanofiltration with a market share of 10% in 2023.

 

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North America Tangential Flow Filtration Market Scope

North America Tangential Flow Filtration Market
Market Size in 2023	USD 640.9 Mn.
Market Size in 2030	USD 1289.21 Mn.
CAGR (2024-2030)	10.5%
Historic Data	2018-2022
Base Year	2023
Forecast Period	2024-2030
Segment Scope	By Product Single-use TFF Systems Reusable TFF Systems Membrane Filters Filtration Accessories
	By Technology Ultrafiltration Microfiltration Reverse Osmosis Nanofiltration
Country Scope	United States Canada Mexico

 

North America Tangential Flow Filtration Market Key Players

• ANDRITZ AG (US)
• Asahi Kasei Corporation (Japan)
• Koch Membrane Systems, Inc. (US)
• Cole-Parmer Instrument Company LLC. (US)
• PendoTECH LLC (US)
• FlexBiosys Inc. (US)
• BIONET (Spain)
• Microfilt India Pvt. Ltd. (India)
• MICRODYN-NADIR GmbH (Germany)
• Synder Filtration Inc. (US)
• ARTeSYN Biosolutions (Ireland)
• Cantel Medical Corporation (US)
• Kuraray Co., Ltd (Japan)
• SYSBIOTECH GmbH (Austria)
• Cobetter Filtration Equipment Co. Ltd. (China)