Tangential Flow Filtration Market: Industry Analysis and Forecast (2024-2030)

Tangential Flow Filtration Market Definition/ Overview:

Tangential flow filtration, also known as cross-flow filtration, is a very important downstream processing technique that is also used in the upstream process of cell harvesting (separation of cells from fermentation broth). The solution is delivered tangentially along the filter's surface, with the pressure difference guiding constituents smaller than the pores through the filter. A wide range of biomolecules, including antibodies, nucleic acids, and recombinant proteins, are separated and purified using tangential flow filtration. This technique has a number of advantages, including the flexibility to be used in a variety of biological domains such as immunology, protein chemistry, molecular biology, biochemistry, and microbiology, as well as its adaptability to a variety of volumes for separation and purification.

Tangential flow filtration is used to concentrate and desalt sample solutions that range in size from a few millilitres to thousands of litres. It has various advantages, including easy scaling up and scaling down, simple set-up and operation, and time and money savings.

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Tangential Flow Filtration Market Dynamics:

Growth in demand of Tangential Flow Filtration Machines – Reverse osmosis and nanofiltration are two common tangential flow filtration techniques. In concentration and diafiltration techniques, tangential flow filtration is used. It boosts a solution's concentration by removing liquids while keeping the solute molecules. Diafiltration is the separation of small and large particles, leaving the smaller particles behind without changing the total concentration by cleaning out the rest of the salt with another buffer at the end. This method can also be used to reduce the concentration of a solution by flushing away the remaining salts with water. Pre-filter constituent Water for Injection (WFI) systems to reduce endotoxins and restore bacterial cultures and viruses are examples of tangential flow filtration applications. During the forecast period 2024-2030, the increased demand of tangential flow filtration is driving the growth of the Tangential Flow Filtration Market.

Technological Innovations in the technology of Tangential Flow Filtration - Microfiltration is a commonly used tangential flow filtration technology. According to a report published in May 2020, Oxford Biomedica (OXB), a leading gene and cell therapy company focused on Lentiviral Vector (LV) technology development, has progressed a GMP LV cell culture production platform from a cell factory-based backing cell technique to a more expandable, serum-free suspension technique operating in single-use bioreactors, which has now been expanded up to 200 L in volume to meet increased LV supply demand. Repligen Corporation (Repligen) developed the TFDF (Tangential Flow Depth Filtration) technique for harvesting lentiviral vectors from cell culture supernatant in the bioreactor. Cells and cell detritus were efficiently separated from vector particles using the TFDF method. Harvest yields were frequently in excess of 90%, with flux rates ranging from 700 to 750 litres/m2/hour (LMH) at both the 5 and 50 L scales. The tangential mode of TFDFTM was discovered to be soft enough on the cells to support numerous harvests, allowing the possibility of greatly increasing LV vector production in a perfusion mode. Tangential Flow Filtration is expected to increase at a rapid pace between 2024 and 2030, owing to these technological advancements.

International mergers in the Tangential Flow Filtration Market – There has been many international mergers in the Tangential Flow Filtration Market and they might help the market to grow in those regions with more fundings and more work force. For example - Solaris (Italy), a firm that designs and manufactures bioprocessing equipment, notably tangential flow filtration systems for use in biotechnology and other life sciences applications, was bought by Donaldson Company (US) in December 2021. The company's pharmaceutical portfolio will be enhanced as a result of this acquisition. Danaher bought the biopharma business from General Electric Company in March 2020. Cytiva will be the name of this division, which will be a stand-alone firm functioning within the Danaher Life Sciences segment. These mergers are some key developments in the market which is expected to drive the Tangential Flow Filtration Market.

High Initial Expenditure – Tangential Flow Filtration Market growth is likely to be hindered by the high capital expenditure necessary to set up new production facilities and the simple availability of product substitutes such as pre-coat filtration, centrifugation, and direct flow filtration. In the forecast period of 2024-2030, complications generated by the interaction of charged excipients and proteins, as well as rigorous government norms and regulations, are expected to provide a challenge to the tangential flow filtration market.

Significant Therapeutical Applications - Recombinant proteins have gained substantial traction for therapeutic uses as a result of the shift in treatment patterns toward focused therapy. Antibody-drug conjugates (ADCs) are a growing biopharmaceutical category that is increasingly being used in oncology. TFF products are used to make recombinant proteins and antibody-drug conjugates (ADCs). The biopharmaceutical industry's tendency of commercialising recombinant proteins is expected to be a great opportunity for the tangential flow filtration market forward.

Increasing use of biomolecules - TFF (tangential flow filtration) is a fast and effective method for separating and purifying biomolecules. It can be used in immunology, protein chemistry, molecular biology (DNA/RNA/oligonucleotides), biochemistry, and microbiology, among other biological domains. TFF has been increasingly popular for concentrating and desalting proteins and peptides, recovering and purifying antibodies or recombinant proteins from cell culture medium, and fractionating dilute protein mixtures over the years.

Tangential Flow Filtration Market Segment Analysis:

By Product, the Tangential Flow Filtration Market is segmented as Single-use TFF Systems, Reusable TFF Systems, Membrane Filters, and Filtration Accessories. Single-use TFF systems has the market share of 35% in 2023 due to benefits such as less cross-contamination, more flexibility, and reduced process time, as well as increased use of techniques such as microfiltration. The expansion of this category is being driven by fully automated single-use systems, which offer benefits such as less validation, lower capital costs, and fewer cleaning requirements. Reusable TFF Systems has the market share of 28% in 2023 as in long run the cost of using these TFFs is very low and as the name suggests, can be reused. It does hinder the quality of filtrations but has some advantages like microfiltration, benefits such as ease of use, quicker application, and greater effectiveness. Filtration accessories are costly and have limited use. Membrane filters held the market share of 16% in 2023. 

By Technology, the Tangential Flow Filtration Market is segmented as Ultrafiltration, Microfiltration, Reverse Osmosis, and Nanofiltration. Microfiltration has the market share of 33% in 2023 followed by Reverse Osmosis with the market share of 31% in 2023. Microfiltration is at the top because of the rising usage of microfiltration in tangential flow filtration for a wide range of applications such as concentration and desalting of protein, peptide, and oligonucleotide solutions Tangential-flow microfiltration can be used to clarify difficult-to-filter solutions such crude plant extracts, which cause membrane fouling quickly when using traditional dead-end filtration techniques, driving the segment's growth. Reverse osmosis has the send largest market share and is the fastest growing segment because of surging application of reverse osmosis in the purification of water and its increased cost-effectiveness in comparison with conventional evaporation techniques. Ultrafiltration has the market share of 23% in 2023 followed by Nanofiltration with the market share of 13% in 2023 because of their limited industrial use and the cost of these filtrations are also ultra-high.

Tangential Flow Filtration Market Regional Insights:

North America held the market share of 35% in 2023, due to growing investments in the acceptance of progressive technology and increased use of tangential flow filtration processes such as reverse osmosis in the North American area Tangential Flow Filtration's expansion in the North American market is being driven by an increase in funding for R&D of several elementary technologies for the biopharmaceutical industry. Europe has the market share of 30% in 2023 due to massive presence of key players in the region like Sartorius AG (Germany), BIONET (Spain), etc. as well as some government policies and government funding have given the market a great boost. Asia Pacific has the market share of 20% in 2023 and is the fastest growing region in the market owing to reasons such as the pharmaceutical industry's rapid growth and the growing popularity of biosimilars the growth of the Tangential Flow Filtration Market in the Asia-Pacific region is being driven by an increasing number of innovative product launches and a growing application of microfiltration. South America has the market share of 10% followed by 5% market share of Middle East & Africa due to low population and weak economies.

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Tangential Flow Filtration Market Scope:

Tangential Flow Filtration Market Key Players

• ANDRITZ AG (US)
• Asahi Kasei Corporation (Japan)
• Koch Membrane Systems, Inc. (US)
• Cole-Parmer Instrument Company LLC. (US)
• PendoTECH LLC (US)
• FlexBiosys, Inc. (US)
• BIONET (Spain)
• Microfilt India Pvt. Ltd. (India)
• MICRODYN-NADIR GmbH (Germany)
• Synder Filtration, Inc. (US)
• ARTeSYN Biosolutions (Ireland)
• Cantel Medical Corporation (US)
• Kuraray Co., Ltd (Japan)
• SYSBIOTECH GmbH (Austria)
• Cobetter Filtration Equipment Co. Ltd. (China)