Protein Labeling Market: Global Industry Analysis and Forecast (2024 -2030)

  • Protein Labeling Market size was valued at USD 2.24 Bn. in 2023. The total Protein Labeling Market revenue is expected to grow by 9.2% from 2024 to 2030, reaching nearly USD 4.15 Bn.

  • Format : PDF | Report ID : SMR_2160

Protein Labeling Market Overview

Protein labeling involves attaching specific molecules such as biotin, enzymes, fluorophores, or radioactive isotopes, to proteins to aid in their detection, purification, or immobilization in biological research. Biotin, for instance, binds strongly to avidin or streptavidin, facilitating robust detection and purification applications. Enzyme labels like horseradish peroxidase (HRP) or alkaline phosphatase (AP) require substrates to produce detectable signals, making them versatile for various assays. Fluorophores, on the other hand, emit light upon excitation and are crucial for applications such as microscopy and flow cytometry due to their specificity and sensitivity.


Protein labeling strategies vary based on the target application, utilizing chemical, enzymatic, or metabolic methods to covalently link labels to proteins or nucleotides. These strategies enable researchers to study protein interactions, localization, and function both in vitro and in vivo, contributing to advancements in fields ranging from basic biological research to diagnostics and drug development.


The Protein Labeling Market has grown immensely due to the advancements in biotechnology, increasing demand for personalized medicine, and growing applications in drug discovery and development. As per the study, it is also expected to grow in the future, driven by ongoing technological advancements and increasing research activities in proteomics. Emerging trends such as bioorthogonal chemistry and multiplexed assays are likely to reshape the landscape, offering new opportunities for market growth and application diversification.

Protein Labeling Market


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Protein Labeling Market Competitive Landscape

As per the study, the Global Market is competitive, driven by technological innovation, market consolidation, initiatives to increase market presence and the diverse applications across research, diagnostics and therapeutics.


  1. The Thermo Fisher Scientific Company is the Protein Labeling Market leader known for its extensive range of labeling reagents and kits, leveraging its broad customer base and global distribution network.  
  2. LGC ASSURE’s INFORMED has launched Informed Protein, a rigorous certification program verifying protein content in supplements. Certified products undergo total nitrogen assessment, carbon/nitrogen ratio evaluation, and free amino acid analysis to ensure accuracy. Facility assessments and blind product sampling further enhance quality assurance. The Informed Protein logo on packaging signifies independent verification of protein claims, offering consumers confidence in product integrity. The program, headquartered in Kentucky, USA, lists certified products on, facilitating transparency through detailed batch information and purchase links. Trusted by brands like Bare Performance Nutrition and PhD Nutrition, it addresses consumer demand for transparency and quality assurance in supplements.


Protein Labeling Market Dynamics

Technological Advancements in Labeling Techniques Driving the Protein Labeling Market Growth

The technological innovations in labeling techniques such as fluorescence labeling, biotinylation, and radioisotope labeling have majorly improved the sensitivity, specificity, and multiplexing capabilities of protein detection methods. These advancements have broadened the application spectrum of protein labeling beyond traditional research settings into clinical diagnostics, personalized medicine, and biotechnology. Thus, driving the growth of the global Protein Labeling Market.


The technologies offered by PerkinElmer, Inc. has specific capabilities tailored to enhance efficiency, sensitivity, and automation in protein analysis and assay development processes. The technologies offered are:


Key Features

LabChip GXII TouchTM microfluidics technology

It enables rapid sample acquisition within less than 40 seconds, making it ideal for medium and high throughput applications. It can analyze up to 96 protein samples in under 1 hour, effectively removing bottlenecks in process development. This microfluidics platform replaces traditional manual gel methods, offering enhanced workflow efficiency and significantly higher throughput.

JANUS BioTXTM Automated Workstation

It provides reliable small-scale purification and sample preparation essential for analytical protein characterization, supporting quality by design experiments in both upstream and downstream processes. It offers versatile functionality with column, tip, and batch chromatography modes integrated into a single instrument, eliminating the need for multiple devices. This enhances efficiency and simplifies workflows in protein analysis and preparation.

AlphaPlex reagent technology

It offers a unified, all-in-one-well system for multiplexing, ensuring ultra-sensitive immunoassay analyses. This technology allows research professionals to obtain comprehensive data more efficiently and with minimal human involvement. AlphaPlex reagents enable the quantification of a wide spectrum of analytes, spanning from nucleotides to large proteins, and facilitate the immunophenotyping of diverse cell populations.

Lance Ultra TR-FRET assay kits

It offer a comprehensive selection of over 60 new kits designed for metabolic, neurology, oncology, and biotherapeutic targets. These assays empower researchers in drug discovery to attain rapid, sensitive, and dependable results. Utilizing Lance Ultra's distinctive ULight™ Acceptor and Eu chelate donor pairs, researchers can conduct a broader range of ultra-sensitive and automation-friendly assays, streamlining and accelerating the discovery process.


Increasing Advancements in Proteomics Creating Opportunities for the Protein Labeling Market Growth

High-throughput mass spectrometry (MS) techniques, such as data-independent acquisition (DIA), have revolutionized protein analysis by enabling reproducible identification across thousands of samples. These methods are crucial for applications like biomarker discovery and drug development. Moreover, single-cell proteomics has emerged as a rapidly growing field, offering insights into cellular heterogeneity and function that were previously inaccessible with bulk analyses. Despite challenges such as sensitivity and throughput, innovations in MS and other technologies continue to expand the proteomics landscape. Future directions include integrating single molecule protein sequencing approaches, promising further advancements in understanding proteoform diversity and its implications in cellular biology and disease mechanisms.


Stable isotope labeling for proteomics offers profound advantages despite complexities in implementation. It facilitates precise comparative analysis by introducing labeled amino acids into proteins either in vivo or in vitro, enabling accurate quantification and identification. In vivo metabolic labeling, where cells are grown in media containing stable isotopes, ensures that proteins are uniformly labeled, crucial for reliable quantitative proteomics. This method not only allows for the comparison of protein abundance between samples but also aids in studying protein turnover dynamics and post-translational modifications. These advantages are expected to drive the Protein Labeling Market in the future by increasing its demand.


The ongoing advancements in mass spectrometry instrumentation and data analysis software promise to streamline these processes, enhancing the reliability and applicability of stable isotope labeling in diverse biological contexts. As researchers continue to refine methodologies and overcome technical hurdles, the full potential of stable isotope labeling in transforming our understanding of cellular dynamics and disease mechanisms is becoming increasingly realized.


High Cost and Accessibility are Key Challenges for the Global Protein Labeling Market

Cost and accessibility are pivotal factors influencing the adoption of protein labeling technologies. The substantial expense associated with labeling reagents and equipment poses a significant barrier, especially for smaller research facilities and institutions operating under tight budgets. These financial constraints often restrict access to advanced labeling methodologies, hindering the scalability of proteomics research and diagnostic applications that heavily rely on extensive labeling.


Moreover, the uneven regional availability of specialized reagents and equipment exacerbates these challenges, creating disparities in technological access across different geographical areas. Addressing these issues requires innovative approaches to reduce costs and enhance the accessibility of labeling technologies, thereby democratizing their use and fostering broader participation in cutting-edge proteomics research and diagnostic practices across the world.


Protein Labeling Market Segment Analysis

Based on Labeling Method: The market is segmented into Product Type, Labeling Method and Bioorthogonal Labeling. The In Vitro Labeling segment is held the largest Protein Labeling Market share in 2023. Chemical methods for protein labeling involve attaching a label to amino acids through chemical groups that react with specific amino acid residues. These reactive groups are detailed in the Crosslinker section of the Pierce Protein Methods library, where they are described for their ability to react with specific moieties on particular amino acids. Some chemical labels can also react non-specifically with C-H and N-H bonds across amino acids. These same reactive groups are employed in labeling nucleic acids.


Enzymatic methods are an alternative for labeling both proteins and nucleic acids. These in vitro techniques utilize polymerases, ATP, and labeled amino acids or nucleotides. While in vitro DNA transcription is straightforward, generating labeled proteins through in vitro translation can be challenging due to the need for accurate protein length, proper folding, and specific post-translational modifications that some commercial kits may not adequately support. The Bioorthogonal Labeling segment is an emerging segment that is expected to grow rapidly during the forecast period. This technique tilizes chemical reactions that occur specifically between the label and the protein, minimizing interference with natural biological processes.

Protein Labeling Market1

Protein Labeling Market Regional Insights

North America Protein Labeling Market dominated the global market with the largest share in 2023. The regulatory environment in the region, especially in the United States, provides a structured framework for the development and commercialization of biotechnological products, including protein labeling technologies. Regulatory agencies such as the FDA ensure safety, efficacy, and quality standards, which are essential for market acceptance and growth. The world's largest biotechnology companies present in the region are specializing in protein labeling technologies. These companies invest heavily in research, driving technological advancements and driving the market with innovative labeling solutions tailored for various applications in research, diagnostics, and therapeutics.


Asia Pacific Protein Labeling Market is expected to grow at a high rate during the forecast period. Countries such as Japan, South Korea, China, and India are at the forefront of technological innovation in biotechnology. Advances in protein labeling techniques, such as fluorescent labeling, enzymatic labeling, and bioorthogonal chemistry, are consistently emerging from research institutions and biotech companies in these countries. The region is increasingly emphasizing personalized medicine approaches tailored to individual genetic profiles.


Protein labeling technologies enable precise identification and characterization of biomarkers, which supports the advancement of personalized diagnostic and therapeutic strategies. Countries such as Australia and New Zealand are leveraging protein labeling for environmental research, food safety, and agricultural biotechnology, contributing to regional market growth.


Protein Labeling Market Scope

Protein Labeling Market Scope

Market Size in 2023

USD 9.6 Bn.

Market Size in 2030

USD 15.52 Bn.

CAGR (2024-2030)


Historic Data


Base Year


Forecast Period



By Product Type




Monoclonal Antibodies



Other Reagents


By Labeling Method

In Vitro Labeling

Nanoparticle Labeling

Site-Specific Labeling

Dye-Based Labeling

Co-Translational Labeling

Enzymatic Labeling


In Vivo Labeling

Radioactive Labeling

Photoreactive Labeling

Bioorthogonal Labeling

By Application

Cell-Based Assays

Fluorescence Microscopy

Mass Spectrometry

Immunological Techniques

Protein Microarray

Regional Scope

North America- United States, Canada, and Mexico

Europe – UK, France, Germany, Italy, Spain, Sweden, Russia, and Rest of Europe

Asia Pacific – China, India, Japan, South Korea, Australia, ASEAN, Rest of APAC

Middle East and Africa - South Africa, GCC, Egypt, Nigeria, Rest of the Middle East and Africa

South America – Brazil, Argentina, Rest of South America


Protein Labeling Market Players

  1. Thermo Fisher Scientific, Inc. [Waltham, Massachusetts, USA]
  2. Merck KGaA [Darmstadt, Germany]
  3. Promega Corporation [Madison, Wisconsin, USA]
  4. F. Hoffmann-La Roche Ltd [Basel, Switzerland]
  5. LGC ASSURE [Teddington, England]
  6. New England Biolabs [Ipswich, Massachusetts, USA]
  7. LI-COR, Inc. [Lincoln, Nebraska, USA]
  8. Danaher (Cytiva) [Washington, D.C., USA]
  9. Jena Bioscience GmbH [Jena, Germany]
  10. PerkinElmer, Inc [Waltham, Massachusetts, USA]
  11. General Electric Company [Boston, Massachusetts, USA]
  12. Kaneka Corporation [Osaka, Japan]
  13. SeraCare Life Sciences Inc [Milford, Massachusetts, USA]
  14. Zedira GmbH [Darmstadt, Germany]
  15. TriLink BioTechnologies LLC [San Diego, California, USA]

Frequently Asked Questions

The Global Protein Labeling Market size was USD 2.24 Bn in 2023.

1.    Protein Labeling Market Introduction
1.1.    Study Assumption and Market Definition
1.2.    Scope of the Study
1.3.    Executive Summary
2.    Global Protein Labeling Market: Competitive Landscape
2.1.    SMR Competition Matrix
2.2.    Competitive Landscape
2.3.    Key Players Benchmarking
2.3.1.    Company Name
2.3.2.    Product Segment
2.3.3.    End-user Segment
2.3.4.    Revenue (2023)
2.3.5.    Company Locations

2.4.    Market Structure
2.4.1.    Market Leaders 
2.4.2.    Market Followers
2.4.3.    Emerging Players

2.5.    Mergers and Acquisitions Details
3.    Protein Labeling Market: Dynamics
3.1.    Protein Labeling Market Trends 
3.2.    Protein Labeling Market Dynamics 
3.2.1.    Protein Labeling Market Drivers
3.2.2.    Protein Labeling Market Restraints 
3.2.3.    Protein Labeling Market Opportunities
3.2.4.    Protein Labeling Market Challenges

3.3.    PORTER’s Five Forces Analysis
3.4.    PESTLE Analysis
3.5.    Value Chain Analysis
3.6.    Regulatory Landscape 
4.    Protein Labeling Market: Global Market Size and Forecast by Segmentation (by Value in USD Mn) (2023-2030)
4.1.    Protein Labeling Market Size and Forecast, by Product Type (2023-2030)
4.1.1.    Kits
4.1.2.    Reagents    Enzymes    Monoclonal Antibodies    Probes/Tags    Protein    Other Reagents
4.1.3.    Services

4.2.    Protein Labeling Market Size and Forecast, by Labeling Method (2023-2030)
4.2.1.    In Vitro Labeling    Nanoparticle Labeling    Site-Specific Labeling    Dye-Based Labeling    Co-Translational Labeling    Enzymatic Labeling    Others
4.2.2.    In Vivo Labeling    Radioactive Labeling    Photoreactive Labeling
4.2.3.    Bioorthogonal Labeling

4.3.    Protein Labeling Market Size and Forecast, by Application (2023-2030)
4.3.1.    Cell-Based Assays
4.3.2.    Fluorescence Microscopy
4.3.3.    Mass Spectrometry
4.3.4.    Immunological Techniques
4.3.5.    Protein Microarray

4.4.    Protein Labeling Market Size and Forecast, by Region (2023-2030)
4.4.1.    North America
4.4.2.    Europe
4.4.3.    Asia Pacific 
4.4.4.    Middle East and Africa 
4.4.5.    South America

5.    North America Protein Labeling Market Size and Forecast by Segmentation (by Value in USD Million) (2023-2030)
5.1.    North America Protein Labeling Market Size and Forecast, by Product Type (2023-2030)
5.1.1.    Kits
5.1.2.    Reagents    Enzymes    Monoclonal Antibodies    Probes/Tags    Protein    Other Reagents
5.1.3.    Services

5.2.    North America Protein Labeling Market Size and Forecast, by Labeling Method (2023-2030)
5.2.1.    In Vitro Labeling    Nanoparticle Labeling    Site-Specific Labeling    Dye-Based Labeling    Co-Translational Labeling    Enzymatic Labeling    Others
5.2.2.    In Vivo Labeling    Radioactive Labeling    Photoreactive Labeling
5.2.3.    Bioorthogonal Labeling

5.3.    North America Protein Labeling Market Size and Forecast, by Application (2023-2030)
5.3.1.    Cell-Based Assays
5.3.2.    Fluorescence Microscopy
5.3.3.    Mass Spectrometry
5.3.4.    Immunological Techniques
5.3.5.    Protein Microarray

5.4.    North America Protein Labeling Market Size and Forecast, by Country (2023-2030)
5.4.1.    United States
5.4.2.    Canada
5.4.3.    Mexico 

6.    Europe Protein Labeling Market Size and Forecast by Segmentation (by Value in USD Million) (2023-2030)
6.1.    Europe Protein Labeling Market Size and Forecast, by Product Type (2023-2030)
6.2.    Europe Protein Labeling Market Size and Forecast, by Labeling Method (2023-2030)
6.3.    Europe Protein Labeling Market Size and Forecast, by Application (2023-2030)
6.4.    Europe Protein Labeling Market Size and Forecast, by Country (2023-2030)
6.4.1.    United Kingdom
6.4.2.    France
6.4.3.    Germany
6.4.4.    Italy
6.4.5.    Spain
6.4.6.    Sweden
6.4.7.    Austria
6.4.8.    Rest of Europe

7.    Asia Pacific Protein Labeling Market Size and Forecast by Segmentation (by Value in USD Million) (2023-2030)
7.1.    Asia Pacific Protein Labeling Market Size and Forecast, by Product Type (2023-2030)
7.2.    Asia Pacific Protein Labeling Market Size and Forecast, by Labeling Method (2023-2030)
7.3.    Asia Pacific Protein Labeling Market Size and Forecast, by Application (2023-2030)
7.4.    Asia Pacific Protein Labeling Market Size and Forecast, by Country (2023-2030)
7.4.1.    China
7.4.2.    S Korea
7.4.3.    Japan
7.4.4.    India
7.4.5.    Australia
7.4.6.    Indonesia
7.4.7.    Malaysia
7.4.8.    Vietnam
7.4.9.    Taiwan
7.4.10.    Rest of Asia Pacific

8.    Middle East and Africa Protein Labeling Market Size and Forecast by Segmentation (by Value in USD Million) (2023-2030)
8.1.    Middle East and Africa Protein Labeling Market Size and Forecast, by Product Type (2023-2030)
8.2.    Middle East and Africa Protein Labeling Market Size and Forecast, by Labeling Method (2023-2030)
8.3.    Middle East and Africa Protein Labeling Market Size and Forecast, by Application (2023-2030)
8.4.    Middle East and Africa Protein Labeling Market Size and Forecast, by Country (2023-2030)
8.4.1.    South Africa
8.4.2.    GCC
8.4.3.    Nigeria
8.4.4.    Rest of ME&A

9.    South America Protein Labeling Market Size and Forecast by Segmentation (by Value in USD Million) (2023-2030)
9.1.    South America Protein Labeling Market Size and Forecast, by Product Type (2023-2030)
9.2.    South America Protein Labeling Market Size and Forecast, by Labeling Method (2023-2030)
9.3.    South America Protein Labeling Market Size and Forecast, by Application (2023-2030)
9.4.    South America Protein Labeling Market Size and Forecast, by Country (2023-2030)
9.4.1.    Brazil
9.4.2.    Argentina
9.4.3.    Rest Of South America

10.    Company Profile: Key Players
10.1.    Thermo Fisher Scientific, Inc.
10.1.1.    Company Overview
10.1.2.    Business Portfolio
10.1.3.    Financial Overview
10.1.4.    SWOT Analysis
10.1.5.    Strategic Analysis
10.1.6.    Recent Developments

10.2.    Merck KGaA
10.3.    Promega Corporation.
10.4.    F. Hoffmann-La Roche Ltd
10.5.    LGC ASSURE
10.6.    New England Biolabs.
10.7.    LI-COR, Inc.
10.8.    Danaher (Cytiva)
10.9.    Jena Bioscience GmbH
10.10.    PerkinElmer, Inc
10.11.    General Electric Company
10.12.    Kaneka Corporation
10.13.    SeraCare Life Sciences Inc
10.14.    Zedira GmbH
10.15.    TriLink BioTechnologies LLC
11.    Key Findings 
12.    Industry Recommendations
13.    Protein Labeling Market: Research Methodology

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